Although a functional SH2 binding domain of CIS was not required for its interaction with IL-2Rβ in vitro, its phosphotyrosine binding capability was essential for the inhibitory action of CIS. Thus, we demonstrate that CIS can negatively control at least two independent IL-2 signaling pathways. Correspondingly, CIS inhibits functions associated with both of these kinases: Lck-mediated phosphorylation of IL-2Rβ and IL-2-mediated activation of Stat5. This interaction requires the A region of IL-2Rβ (residues 313–382), which also mediates the association of IL-2Rβ with Lck and Jak3. We now demonstrate that CIS also interacts with the IL-2 receptor β chain (IL-2Rβ). CIS is known to associate with the IL-3 receptor β chain and erythropoietin receptor and to inhibit signaling mediated by IL-3 and erythropoietin. Glycobiology and Extracellular MatricesĬIS is a cytokine- induced SH2-containing protein that was originally cloned as an interleukin (IL)-3-inducible gene.Now you will get a PDF file to download it.After the option is selected, click on the “View” button.After selecting the district, you have to select the Part Number from the list.On this Page, select “ Assembly Segment”.There is an option to see the voter slip, by clicking on it, see the voter slip.You will find all the information like AC number, serial number, name, father / husband’s name, age and epic number or voter ID number.After clicking on the Show button, all search results will be shown.
Then, enter further details such as Name, Father’s Name Gender, Age etc.After that, Select Your Constituency & Part Number.Now you have to select your district from the drop-down list.How to Search Name in Bihar Voter List 2020 People also call it a Bihar election electoral roll. Likewise, now all the residents of Bihar can check the Bihar Voter List online.Bihar Voter List is a document that includes the names of all eligible voters for any upcoming election. Bihar Voter List 2020 | In order to provide online services, Bihar Government is very active, now you can check online ration card list of residents of Bihar, caste certificate and family register etc online.
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